Below is a series of key publications that form the conceptual foundation of the laboratory’s new research program

Publications

Screenshot of a scientific journal article titled 'Targeting Glioblastoma Cell State Plasticity for Enhanced Therapeutic Efficacy' from bioRxiv.

BioRxiv

Demonstrates how transcriptional plasticity drives therapeutic resistance and provides the conceptual foundation for targeting state-dependent vulnerabilities.

2026

Title page of a scientific article titled "Modeling medulloblastoma pathogenesis and treatment in human cerebellar organoids," authored by Thomas Willott and others, published by Cold Spring Harbor Laboratory Press.

Genes & Development

Defines developmental origins and therapeutic vulnerabilities in brain tumours using human organoid models, supporting state-based interpretations of tumour heterogeneity.

2026

Title of a research article from EMBO Molecular Medicine discussing a new model for glioblastoma recurrence to identify therapeutic vulnerabilities, with authors listed and section headings for abstract and introduction.

EMBO Molecular Medicine

Establishes a longitudinal PDX model of glioblastoma recurrence, supporting investigation of epigenetic evolution and therapy resistance.

2025

A scientific article titled 'Three-dimensional regulatory hubs support oncogenic programs in glioblastoma,' showing diagrams of 3D GSC hub identification, 3D hub properties, targeting strategies, and associated cancer types, with sections on highlights, authors, correspondence, and a brief overview.

Molecular Cell

Integrated scRNAseq and bulk epigenetic sequencing (HiC) approaches to identify chromatin hubs that coordinate oncogenic gene expression in glioblastoma.

2025

Title page of a scientific journal article titled "Disruption of DNA methylation underpins the neuroinflammation induced by targeted CNS radiotherapy." It includes authors' names, their affiliations, and keywords related to radiotherapy, epigenetics, neuroinflammation, neuro-oncology, DNA methylation, and transcriptomics. The page provides an abstract summary discussing DNA methylation and neuroinflammation effects from targeted radiotherapy treatments.

Brain

2025

Links DNA methylation changes to treatment-induced microenvironmental remodelling, highlighting epigenetic responses to therapy.

Title and abstract of a scientific article from Acta Neuropathologica Communications discussing how chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth, including research on glioma stem cells, tumor development, and related experimental findings.

Acta Neuropath Comms

2024

Demonstrates how microenvironmental stress promotes stem-like states, linking external signals to tumour plasticity.

Figure depicting lineage regulation in glioblastoma by METTL7B, including gene expression, tumor invasion, and cellular differentiation pathways.

Cell Reports

Identifies molecular regulators of glioblastoma lineage states, supporting mechanisms of transcriptional heterogeneity.

2024

Title page of a scientific research review article titled 'Diffuse Glioma Heterogeneity and Its Therapeutic Implications', authored by James G. Nicholson and Howard A. Fine, published in March 2021 in Cancer Discovery, showing the abstract, introduction, and author details.

Cancer Discovery

2021

Influential review shaping current understanding of glioblastoma heterogeneity and plasticity.

Scientific journal cover titled 'Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas' with a colorful, dot-patterned brain illustration graphic.

Cancer Discovery

Establishes organoid-based models as faithful systems to study glioblastoma cellular states and tumour microenvironment interactions.

2020

A screenshot of a scientific journal article webpage titled "Disruption of the Wnt-antagonist Apc in the pituitary stem cells drives the development of adamantinomatous craniopharyngioma" from bioRxiv. The page includes the article's authors, a link to the full text, and an abstract summarizing the research on tumor development in pituitary stem cells.

EMBO Molecular Medicine

Establishes APC dysfunction as a distinct genetic driver of adamantinomatous craniopharyngioma, independent of CTNNB1 mutations.

2026 (in Print)